Multimodality Neuroimaging: Research and Clinical Applications

Abstract

This manuscript reviews the current
stance and the pertinent problems of
transcranial magnetic stimulation (TMS)
and functional magnetic resonance imaging
(fMRI) as brain mapping methodologies.
The missing structure-function
relation limits the use of TMS, whereas
the uncertainty about the functional
significance of activated cortical regions
might render interpretation of fMRI
studies difficult. Advances in image
processing, however, allowed for 3-
dimensional real-time visual guidance of
TMS and integration with fMRI data. We
describe the method used to coregister
TMS and fMRI and present examples
where a multimodality neuroimaging approach
might add to our understanding of
normal and pathological brain function.