Characterizing Neuropathies Associated With Monoclonal Gammopathy of Undetermined Significance (MGUS): A Framework Consistent With Classifying Injuries According to Fiber Size
Abstract
Neuropathies associated with monoclonal
gammopathy of undetermined
significance (MGUS) occur frequently in
the elderly. Data from 42 consecutive elderly
patients with a MGUS-associated
neuropathy—12 patients with IgM
MGUS, 25 patients with IgG MGUS, 5
patients with IgA MGUS—were evaluated
prospectively using quantifiable
clinical criteria and quantitative sensory
testing. Results consistent with preferential
injury to large fibers were found
in patients with IgM isotypes (P .005)
but not in patients with IgG isotypes (P
.0005 to .0004). These findings support
an immunologic origin for at least
some MGUS-associated neuropathies
and provide information important for
the clinical evaluation of neuropathies
in the elderly.
gammopathy of undetermined
significance (MGUS) occur frequently in
the elderly. Data from 42 consecutive elderly
patients with a MGUS-associated
neuropathy—12 patients with IgM
MGUS, 25 patients with IgG MGUS, 5
patients with IgA MGUS—were evaluated
prospectively using quantifiable
clinical criteria and quantitative sensory
testing. Results consistent with preferential
injury to large fibers were found
in patients with IgM isotypes (P .005)
but not in patients with IgG isotypes (P
.0005 to .0004). These findings support
an immunologic origin for at least
some MGUS-associated neuropathies
and provide information important for
the clinical evaluation of neuropathies
in the elderly.
Keywords
fiber size, immunologic, monoclonal gammopathy of undetermined significance (MGUS), neuropathy, quantitative sensory testing (QST)
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