Factors in cerebrospinal fluid (CSF) of
patients with relapsing-remitting multiple
sclerosis (MS) interfere with neuronal
Na+ channels and thereby reduce
neuronal excitability. The nature of such
factors is still unknown. The CSF from patients
with secondary progressive MS,
however, did not contain this anti-excitatory
activity, and therefore further efforts
in the identification of these factors
should concentrate on molecules specifically
present in CSF during relapses.